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Google “CBD oil” and you’ll find pages and pages of articles, ads and studies. Makers claim the popular hemp extract-sold online and available in many states in health and natural food stores-may help treat a long list of health problems, from acne to anxiety, chronic pain to cancer. But is it safe, and does it work? Here’s a quick guide to what you need to know.
What is CBD?
CBD is a natural compound called a cannabinoid found in hemp and marijuana, two varieties of theCannabis sativaplant. Cannabinoids influence signaling pathways between cells (basically how cells talk to each other), potentially impacting multiple systems in your body. However, unlike its chemical cousin THC (which is only in marijuana), CBD does not have psychoactive effects, meaning it won’t get you stoned. “In fact, our bodies naturally churn out chemicals that are very similar to CBD,” says Debbie Petitpain, M.S., R.D.N., spokesperson for the Academy of Nutrition and Dietetics.
Does CBD Oil Work?
“There may be some benefit for those with sleep problems, anxiety or pain, but the evidence to support this is largely anecdotal,” says Brent A. Bauer, M.D., director of research for the Integrative Medicine and Health Program at the Mayo Clinic in Rochester, Minnesota. Currently, there’s a lack of high-quality studies in humans about CBD’s efficacy. That’s because prior to the 2018 Farm Bill, which made CBD derived from hemp federally legal, hemp was highly restricted. “This made it very difficult for medical centers to obtain products to test in clinical trials,” says Bauer. “Basically, obtaining CBD required a lot of red tape, which discouraged research.”
Most of the studies showing promise have been conducted with mice. A report in theEuropean Journal of Painshowed that topical CBD diminished pain and inflammation associated with arthritis in rodents. And rats that were given CBD for seven days displayed fewer signs of pain and anxiety, according to a 2010 study in the journalPain. Another report—this one a review of research in the journalNeuropsychopharmacology Reviews—boldly stated that there’s “an overwhelming body of convincing preclinical evidence” (preclinical meaning not tested in humans) that indicates cannabinoids can block inflammatory and nerve-based pain. But according to Petitpain, “We need more clinical research to really show who benefits, and at what dose.”
(Sativex is already available in 29 countries.)
Is CBD Safe?
What’s Next For CBD?
Mariano, for one, is working hard to make sure that more research is in our future. He and fellow members of the American Society of Anesthesiologists recently endorsed bills in the House and the Senate that seek to increase the number of high-quality, registered manufacturers that produce cannabinoids for research purposes. “Once we do that, researchers can actually get what they need to do studies on CBD,” says Mariano. “We know that there are many different types of cannabinoids that potentially have medical use, which is exciting. And clearly a lot of people, physicians included, are trying to find new ways to manage health issues. Until then, we are still very much in pioneer territory.”
Holly Pevzner
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