In This ArticleView AllIn This ArticleWhat Is a GLP-1?Eriomin Lemon Fruit ExtractSupresa Saffron ExtractMorosil Red Orange Fruit ExtractIs Lemme GLP-1 Daily Safe?
In This ArticleView All
View All
In This Article
What Is a GLP-1?
Eriomin Lemon Fruit Extract
Supresa Saffron Extract
Morosil Red Orange Fruit Extract
Is Lemme GLP-1 Daily Safe?
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Photo:Kardashian: Nathan Congleton/NBCU Photo Bank/Getty Images. Product: Courtesy of Brand.
Kardashian: Nathan Congleton/NBCU Photo Bank/Getty Images. Product: Courtesy of Brand.
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Boasted as being a “breakthrough capsule formula designed to boost GLP-1 hormone levels, reduce hunger and cravings and support healthy weight management,” the supplement contains three clinically studied, patented ingredients: Eriomin Lemon Fruit Extract, Supresa Saffron Extract, and Morosil Red Orange Fruit Extract.
Kardashian’s supplement, however, is not a GLP-1 agonist. It contains ingredients called nutraceuticals that are being touted as raising your body’s natural levels of GLP-1. A press release about the supplement claims that the three ingredients in Lemme GLP-1 Daily have been “shown in clinical studies to deliver significant weight management benefits.”
Let’s take a closer look at what the studies actually show regarding these ingredients.
Eriomin is the patented nutraceutical formula based on eriocitrin, a citrus flavonoid found in lemon juice and lemon peel. According to a 2022 study in theJournal of Medicinal Food, Eriomin is made up of 70% eriocitrin, 5% hesperidin, 4% naringin, 1% didymin and 20% a mix of different types of fiber, including cellulose, pectin, lignan, cutin and suberin.
All three human studies were small as far as the number of participants. One included 30 participants, another 103 and the other 45. And all three studies had similar results, suggesting that participants with prediabetes who took at least 200 milligrams per day of Eriomin for 12 weeks showed improvements in GLP-1 blood levels and blood sugar levels, among other things—like a healthier microbiome, likely due to the fiber in the Eriomin.
This study used female participants who were healthy and mildly overweight, 31 of whom took 176.5 milligrams of Satiereal in capsule form twice daily over eight weeks. The other participants took a placebo. The study results indicate that the group who took Satiereal had a greater reduction in body weight compared to the placebo group—an average of -0.96 kg compared to -0.01 kg. The Satiereal group also reduced their snacking, suggesting that the supplement may create a satiating effect which may lead you to eat less, and may result in weight loss.
Morosil Red Orange Fruit Extract comes from Moro red oranges, which are a type of blood orange. They’re found in Italy, as is the company that makes Morosil. As with the other ingredients in Lemme GLP-1 Daily, there haven’t been many studies done specifically on Morosil. A study is mentioned on themanufacturer’s websitebut there’s no citation or link to it, so it’s difficult to know if the results are accurate. They appear to line up with a 2015 study that suggests that those who took 400 milligrams per day of Morosil supplementation over 12 weeks had greater reductions in weight, waist circumference and hip circumference compared to the group who received a placebo.Physical activity was not encouraged, nor were dietary restrictions, like reducing calorie intake. However, because the full study is not readily available online, it is also unknown who funded the study.
A more recent 2022 study tested 400 milligrams daily of Morosil for six months and its effect on weight loss in overweight but otherwise healthy men and women compared to placebo.Participants in both groups were instructed to walk for 30 minutes three times per week. They were also provided with calorie-controlled diets. Participants did not know if they were taking Morosil or a placebo but were instructed to take their supplement once a day. The participants in the Morosil group had greater reductions in weight and hip and waist circumference compared to the placebo group. Bionap, the company that manufactures Morosil, paid for this research—hence, yet again, a greater risk of results bias.
The studies we found suggest that the individual patented ingredients in Lemme GLP-1 Daily appear to be safe. Most of the adverse effects were in the form of gastrointestinal distress, like diarrhea, gas and bloating.
Since there are currently no studies on the specific combination of all three of these ingredients—as in the Lemme GLP-1 Daily—it’s difficult to determine whether they’re safe and effective when combined. As usual, we highly recommend talking with your health care practitioner or a registered dietitian before shelling out the $72 per month subscription fee for this supplement.
Though there has not been much research done specifically on the patented extracts in Kardashian’s supplement—and what has been done may be biased—it is important to note that there is research on the plants that the extracts come from. For example, a 2023 study suggests that adolescents who were overweight and took a 60-milligram capsule of saffron each day for 12 weeks had greater reductions in BMI and waist circumference compared to those who took a placebo.There were also reductions in fasting triglycerides and increases in HDL (“good”) cholesterol.
Another 2024 review inNutrition Reviewssuggests that the regular consumption of citrus fruits may have a beneficial effect on metabolism and body weight, but more well-designed human trials need to be conducted since current evidence is mixed.
“Extracts can be more potent because their phytonutrients are easier for the body to absorb,” saysChrista Brown, M.S., RDN, LD, a registered dietitian specializing in diabetes and blood sugar management. “However, it’s important to remember that the extraction process also removes other nutrients like fiber, water and vitamins.”
The Bottom Line
“Supplements are tricky because they are not regulated in the same way as prescription drugs,” says Kerri McKinley, RPh, pharmacist in charge at North Country Healthcare in Lancaster, New Hampshire. “So they can make all kinds of claims and have zero to minimal effectiveness.”
Brown reiterates how limited human studies are for GLP-1 supplements like Kardashian’s, making it difficult to believe the claims that they are solely responsible for the desired results.
“In my practice, I’m choosing not to recommend this supplement because the research is limited and the product is expensive for the patients I serve,” says Brown. “I would rather support my patients’ improvements in fiber intake and stress-reducing activities, like movement, which support blood sugar and act as a powerful management tool to support emotional eating. Both of these strategies are grounded in research with multiple studies in humans.”
If you’re going touse supplements, we highly recommend using ones that have been independently verified. This ensures quality and that what the label says is what you’re actually getting. As far as we can tell, Lemme GLP-1 Daily has not been independently verified.
Whether you decide to try this supplement or not, remember that no pill replaces health habits, including eating a balanced diet with a variety of foods, regularly moving your body, managing your stressors, getting plenty of quality sleep and spending time with your loved ones. And having a lower number on the scale does not ensure good health if you’re not engaging in healthy habits. For example, there is evidence that physical activity is more important than the number on the scale regarding reducing health risks.
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Sources
EatingWell uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable and trustworthy.
PR Newswire.Lemme innovates with natural GLP-1 supplement, launching September 16th.
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Ribeiro C, Ramos F, Manthey J, et al.Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: a double‐blind, randomized, controlled study.Phytotherapy Research.2019. doi: 10.1002/ptr.6386
Šošić-Jurjević B, Borković-Mitić S, Pavlović S.Lemon flavonoid extract Eriomin® improves pro/antioxidant status and interferes with cholesterol metabolism without affecting serum cholesterol levels in aged rats.International Journal of Molecular Sciences. 2024. doi: 10.3390/ijms25105221
Gout B, Bourges C, Paineau-Dubreuil S.Satiereal, aCrocus sativusL extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women.Nutrition Research. 2010. doi: 0.1016/j.nutres.2010.04.008
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Briskey D, Malfa G, Rao A.Effectiveness of “moro” blood orangeCitrus sinesisOsbeck (Rutaceae) standardized extract on weight loss in overweight but otherwise healthy men and women—a randomized double-blind placebo-controlled study.Nutrients.2022. doi: 10.3390/nu14030427
Kotanidou E, Tsinopoulou V, Giza S, et al.The effect of saffron kozanis (Crocus sativusL.) supplementation on weight management, glycemic markers and lipid profile in adolescents with obesity: a double-blinded randomized placebo-controlled trial.Children. 2023. doi: 10.3390/children10111814
Aslan M, Sukan-Karaçağıl B, Acar-Tek N.Roles of citrus fruits on energy expenditure, body weight management, and metabolic biomarkers: a comprehensive review.Nutrition Reviews. 2024. doi: 10.1093/nutrit/nuad116
